姓    名

张昌源

性    别

男

出生年月

198805

学科专业

有机化学

毕业院校

华南理工大学

学    位

博士

职    称

副教授

现任职务

联系电话

18979597115

电子邮件

zcywood@163.com

学科方向

工业药学

研究方向

有机合成方法学的建立及其在药物分子修饰中的应用

科研课题（主要承担和参与的科研项目）

1.  基于Tf₂O/M介导烯胺酮选择性构建氮杂环的反应研究，国家自然科学基金（地区基金），22361045，32万，2024.1-2027.12，主持,在研。

2.  基于三氟甲磺酸活化烯胺酮的串联反应研究，江西省教育厅科学技术研究项目，GJJ2201726,3万，2023.1-2024.12，主持，在研。

3.  基于磷自由基参与的环己炔双磷化反应研究，国家自然科学基金（青年基金），21901223，21万，2020.1-2022.12，主持，结题。

4.  环炔前体的制备以及环炔的磺酰自由基加成反应研究，江西省教育厅科学技术研究项目，GJJ180839，3万，2019.1-2020.12，主持，结题。

代表性学术论著 (译著、教材)、论文、发明专利

1. Changyuan   Zhang,* Jianping Lin, Li Wang, Yingxuan Mei,   Lanjing Wang, Yuqing Xie, Yu Lu, Jiakai Tian, Wei Wang, Lulu Chen, Mengping   Guo, and Cailong Zhou, Tf2O-Mediated Tandem Reaction of Enaminones for the   Synthesis ofFunctionalized Conjugated-Enals/β-Naphthalaldehydes, J. Org.   Chem. 2024, 89, 373−378

2. Changyuan   Zhang,* Wei Wang, Xuncheng Zhu, Lulu Chen,   Hejiang Luo,* Mengping Guo, Dan Liu, Fan Liu, Huisheng Zhang, Qi Li, and   Jianping Lin, Synthesis of Indolizines via Tf2O‑Mediated Cascade Reaction of Pyridyl-enaminones with   Thiophenols/Thioalcohols, Org. Lett. 2023, 25, 1192−1197;

3. Changyuan   Zhang,* Jian Luo, Jiantao Zhang, Lulu Chen,   Xuncheng Zhu, Mengping Guo, Chan Shen, Zeng Li, and Wei Wang, Tf2O-Mediated   Regioselective C(sp2) H Sulfenylation of Enaminones Using Methyl Sulfoxides   as Sulfur Sources, Asian J. Org. Chem. 2022, 11, e202200014;

4. Changyuan   Zhang,* Huosheng Guo, Lulu Chen,* Jiantao Zhang,   Mengping Guo, Xuncheng Zhu, Chan Shen, and Zeng Li, One-Pot Synthesis of   Symmetrical and Asymmetrical 3‑Amino Diynes   via Cu(I)-Catalyzed Reaction of Enaminones with Terminal Alkynes, Org. Lett.   2021, 23, 8169−8173;

5. Changyuan   Zhang,* Yun Qiu, Jiantao Zhang, Lulu Chen,   Shuting Xu, Huosheng Guo, Jian Luo, and Yao Tan, CAN-mediated Oxidative   Coupling-Reaction of Xanthenes with Enaminones, Asian J. Org. Chem. 2021, 10,   160-163;

6. Changyuan   Zhang, Lianfen Chen, Kai Chen, Chuntao Wang,   Zurong Xu, Huanfeng Jiang and Shifa Zhu, Cu(I)-Catalyzed stereoselective   synthesis of trisubstituted Z-enol esters via interrupting the   1,3-O-transposition reaction, Org. Chem. Front., 2018, 5, 2510-2514;

7. Changyuan   Zhang, Lianfen Chen, Kai Chen, Huanfeng Jiang and   Shifa Zhu, Iron/zinc-catalyzed benzannulation reactions of   2-(2-oxo-alkyl)benzketones leading to naphthalene and isoquinoline   derivatives, Org. Chem. Front., 2018, 5, 1028-1033;

8. Changyuan   Zhang, Huanfeng Jiang and Shifa Zhu,   Gold-catalyzed ring-expansion through acyl migration to afford furan-fused   polycyclic compounds, Chem. Commun., 2017, 53, 2677-2680;

9. Lili   Chen, Changyuan Zhang, Chunxiao Wen, Kun Zhang, Wenfeng Liu, Qian   Chen, Gold-catalyzed cyclotrimerization of arynes for the synthesis of   triphenylenes; Catalysis Communications 65 (2015) 81-84;

10. Qian   Chen, Changyuan Zhang, Chunxiao Wen, Jin Fang, Zhiyun Du, Dongling Wu,   Platinum- and gold-catalyzed hydroalkoxylation and tetramerization of   propiolate esters, Catalysis Communications 56 (2014) 101-105;

11. Qian   Chen, Changyuan Zhang, Lili Chen, Chunxiao Wen, Zhiyun Du, Huixiong   Chen, Kun Zhang, a-Monoarylation and tandem arylation–insertion of malonates with arynes,   Tetrahedron Letters 56 (2015) 2094-2097;

12. Tian-Yu   Sun, Kai Chen, Changyuan Zhang, Tingting You, and Penggang Yin,   1,3-O-Transposition or Trisubstituted Z-Enol Ester? A Comparative Study of   Reactions of Ynones, Chem. Asian J. 2019, 14, 1941-1944;

Jingcheng Du, Changyuan Zhang,   Hong Pu, Yufeng Li, Saimeng Jin, Luxi Tan, Cailong Zhou, Lichun Dong; HKUST-1   MOFs decorated 3D copper foam with superhydrophobicity/superoleophilicity for   durable oil/water separation, Colloids and Surfaces A 573 (2019) 222-229.

一种苯基硫代二苯磷酸酯的制备方法，CN 110563760 B, 2022.2.11 (授权发明专利)

学术兼职、荣誉称号及获奖情况