研究领域与方向

西药与植物提取化合物抗肿瘤与抗前列腺肥大药理机制研究

科研课题（主要承担和参与的科研项目）

1.2019年江西省教育厅科技项目,甲基莲心碱及衍生物经细胞凋亡抗前列腺癌机制研究，在研，主持

2.2019年度宜春学院地方发展研究中心平台项目,多靶点活性化合物抗良性前列腺增生平台构建,在研,主持

3.台湾省教育部门,Quinazoline类药物干扰NGF/TrkA/p75NTR讯息传递抑制摄护腺细胞生长,已结题，主持

4.台湾省教育部门,鱼油抑制摄护腺癌细胞之Toll Like Receptor 9讯息传递所引起的发炎反应与癌转移,已结题，主持

5.台湾省教育部门,生姜活性萃取物于抗药性摄护腺癌之开发,已结题，主持

6.台湾省教育部门,鱼油抵抗摄护腺癌细胞之Toll Like Receptor 4讯息传递所引起的发炎反应与降低化疗药物的抗性，已结题，主持

7.ZBTB-1蛋白在乳腺癌干细胞和化疗抗性中的作用及其机制研究,在研，参与

8.Notch1 通路在一枝黄花提取物抗肿瘤活性的作用,在研，参与

代表性学术论著 (译著、教材)、论文

一、第一或通讯作者发表的主要学术论文

1. Chi-Ming Liu^*# ,Zhengping Wu^#, Bo Pan, Lijie An, Conglei Zhu, Jiqin Zhou, Yinjie Jiang. The antiandrogenic effect of neferine, liensinine, and isoliensinine by inhibiting 5-α-reductase and androgen receptor expression via PI3K/AKT signaling pathway in prostate cancer. Pharmazie, 2021;76(5):225-231.

2. Lijie An*, Zichen Shao, Mengqiao Su, Chi-Ming Liu*. The Traditional Chinese Medicine in the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2.

Chinese Traditional Medicine Journal, 2021;4(1):1-11

3. Zhenping Wu, Chung-Yi Chen, Chiu-Li Kao, Yinjie Jiang, Chi-Ming Liu*. Docosahexaenoic acid inhibits lipopolysaccharide-induced metastatic activities by decreasing inflammation on prostate cancer cell. Pharmazie, 2019;74(11):675-679.

4. Chung-Yi Chen, Chiu-Li Kao, Chi-Ming Liu*. The Cancer Prevention, Anti-Inammatory and Anti-Oxidation of Bioactive Phytochemicals Targeting the TLR4 Signaling Pathway. International Journal of Molecular Sciences, 2018;19(9):2729.

5. Chi-Ming Liu, Mei-Hui Perng, Chung-Yi Chen. The antioxidation and antiproliferation activity of flavonoids from Aquilaria agallocha and Aquilaria sinensis. Biomedical Research, 2018;29 (10):2191-2196

6. Chi-Ming Liu, Mei-Hui Perng*, Chung-Yi Chen*. Antioxidant activities of crude extracts from peel and seed of Cinnamomum camphora. Biomedical Research, 2018;29 (13):2854-2858

7. Chiu-Li Kao ^#, Ying Chen Hung^#, Chi-Ming Liu*. The Pharmacological Effect of Omega-3 Fatty Acids Prevent Cancer Progression in Colon and Breast Cancer. Austin Journal of Nutrition and Food Sciences, 2017; 5(2): 1090.

8. Mei-Yin Chang^#, Chi-Ming Liu^#, Den-En Shieh, Chung-Yi Chen*. Evaluation and analysis of phytochemical antioxidant capacity. Biomedical Research, 2017;28 (14):6431-6434.

9. Chi-Ming Liu, Chiu-Li Kao, Yu-Ting Tseng, Yi-Ching Lo*, Chung-Yi Chen*. Ginger Phytochemicals Inhibit Cell Growth and Modulate Drug Resistance Factors in Docetaxel Resistant Prostate Cancer Cell. Molecules, 2017;22(9):1477.

10. Liang-Chien She^#, Chi-Ming Liu^#, Ching-Tong Chen, Hsing-Tan Li, Wei-Jen Li*, Chung-Yi Chen*. The anti-cancer and anti-metastasis effects of phytochemical constituents

from Leucaena leucocephala. Biomedical Research, 2017;28(7):2893-2897

11. Chi-Ming Liu, Hung-Chun Yeh, Song-Chih Huang, Cheng-Ta Li* and Chung-Yi Chen*. The Antioxidation and Antiproliferation Activity of New Flavonoids from the Leaves and Stems of Cinnamomum reticulatum Hayate. Medicinal chemistry, 2015:5(2):064-066

12. Chi-Ming Liu, Chiu-Li Kao, Hui-Ming Wu, Wei-Jen Li, Cheng-Tsung Huang*, Hsing-Tan Li* and Chung-Yi Chen*. Antioxidant and Anticancer Aporphine Alkaloids from the Leaves of Nelumbo nucifera Gaertn. cv. Rosa-plena. Molecules, 2014; 19:17829-17838

13. Chi-Ming Liu, Ya-Chin Fan, Yi-Ching Lo, Bin-Nan Wu, Jwu-Lai Yeh, Ing-Jun Chen*. Cyclic guanosine monophosphate-enhancing reduces androgenic extracellular regulated protein kinases-phosphorylation/Rho kinase II-activation in benign prostate hyperplasia. International Journal of Urology, 2013;21(1):87-92.

14. Hsing-Tan Li, Hui-Ming Wu, Hsin-Liang Chen, Chi-Ming Liu*, Chung-Yi Chen*. The Pharmacological Activities of (−)-Anonaine. Molecules, 2013;18:8257-8263.

15. Chi-Ming Liu, Yi-Ching Lo, Ming-Hong Tai, Bin-Nan Wu, Wen-Jeng Wu, Yii-Her Chou, Chee-Yin Chai, Chun-Hsiung Huang, Ing-Jun Chen*. Piperazine-Designed alpha(1A)/alpha(1D)-Adrenoceptor Blocker KMUP-1 and Doxazosin Provide Down-Regulation of Androgen Receptor and PSA in Prostatic LNCaP Cells Growth and Specifically in Xenografts. Prostate, 2009; 69(6): 610-623.

16. Chi-Ming Liu, Yi-Ching Lo, Bin-Nan Wu, Wen-Jeng Wu, Yii-Her Chou, Chun-Hsiung Huang, Li-Mei An, and Ing-Jun Chen*. cGMP-Enhancing- and α1A/α1D-Adrenoceptor Blockade-Derived Inhibition of Rho-KinasebyKMUP-1 Provides Optimal Prostate Relaxation and Epithelial Cell Anti-Proliferation Efficacy. Prostate, 2007;67(13):1397-1410.

二、教材

1.解剖生理学 作者：邓志娟,冯琮涵,刘棋铭,吴惠敏,唐善美,许淑芬,江若华,黄嘉惠,汪蕙兰,李建兴,王子绫, 利瓦伊贞, 庄礼聪 出版社：新文京

2.新护理师宝典病理学 作者：林靖蓉,高久理,刘棋铭编着 出版社：永大