姓    名

张昌源

性    别

男

出生年月

1988.05.16

学科专业

药物研发与生产技术

毕业院校

华南理工大学

学   位

博士研究生

职    称

讲师

现任职务

联系电话

18979597115

电子邮件

zcywood@163.com

研究领域与方向

合成方法学的建立及其在药物分子修饰中的应用

科研课题（主要承担和参与的科研项目）

1. 基于Tf2O/M介导烯胺酮选择性构建氮杂环的反应研究，国家自然科学基金（地区基金），22361045，32万，2024.1-2027.12，主持,在研。

2. 基于三氟甲磺酸活化烯胺酮的串联反应研究，江西省教育厅科学技术研究项目，GJJ2201726,3万，2023.1-2024.12，主持，在研。

3. 基于磷自由基参与的环己炔双磷化反应研究，国家自然科学基金（青年基金），21901223，21万，2020.1-2022.12，主持，结题。

4. 环炔前体的制备以及环炔的磺酰自由基加成反应研究，江西省教育厅科学技术研究项目，GJJ180839，3万，2019.1-2020.12，主持，结题。

5. 基于炔烃的串联反应研究（博士启动项目）主持。

代表性学术论著 (译著、教材)、论文

1. Changyuan Zhang,* Wei Wang, Xuncheng Zhu, Lulu Chen, Hejiang Luo,* Mengping Guo, Dan Liu, Fan Liu, Huisheng Zhang, Qi Li, and Jianping Lin, Synthesis of Indolizines via Tf2O‑Mediated Cascade Reaction of Pyridyl-enaminones with Thiophenols/Thioalcohols Org. Lett. 2023, 25, 1192−1197;

2. Changyuan Zhang,* Jian Luo, Jiantao Zhang, Lulu Chen, Xuncheng Zhu, Mengping Guo, Chan Shen, Zeng Li, and Wei Wang, Tf2O-Mediated Regioselective C(sp2) H Sulfenylation of Enaminones Using Methyl Sulfoxides as Sulfur Sources, Asian J. Org. Chem. 2022, 11, e202200014;

3. Changyuan Zhang,* Huosheng Guo, Lulu Chen,* Jiantao Zhang, Mengping Guo, Xuncheng Zhu, Chan Shen, and Zeng Li, One-Pot Synthesis of Symmetrical and Asymmetrical 3‑Amino Diynes via Cu(I)-Catalyzed Reaction of Enaminones with Terminal Alkynes, Org. Lett. 2021, 23, 8169−8173;

4. Changyuan Zhang,* Yun Qiu, Jiantao Zhang, Lulu Chen, Shuting Xu, Huosheng Guo, Jian Luo, and Yao Tan, CAN-mediated Oxidative Coupling-Reaction of Xanthenes with Enaminones, Asian J. Org. Chem. 2021, 10, 160-163;

5. Changyuan Zhang, Lianfen Chen, Kai Chen, Chuntao Wang, Zurong Xu, Huanfeng Jiang and Shifa Zhu, Cu(I)-Catalyzed stereoselective synthesis of trisubstituted Z-enol esters via interrupting the 1,3-O-transposition reaction, Org. Chem. Front., 2018, 5, 2510-2514;

6. Changyuan Zhang, Lianfen Chen, Kai Chen, Huanfeng Jiang and Shifa Zhu, Iron/zinc-catalyzed benzannulation reactions of 2-(2-oxo-alkyl)benzketones leading to naphthalene and isoquinoline derivatives, Org. Chem. Front., 2018, 5, 1028-1033;

7. Changyuan Zhang, Huanfeng Jiang and Shifa Zhu, Gold-catalyzed ring-expansion through acyl migration to afford furan-fused polycyclic compounds, Chem. Commun., 2017, 53, 2677-2680;

8. Lili Chen, Changyuan Zhang, Chunxiao Wen, Kun Zhang, Wenfeng Liu, Qian Chen, Gold-catalyzed cyclotrimerization of arynes for the synthesis of triphenylenes; Catalysis Communications 65 (2015) 81-84;

9. Qian Chen, Changyuan Zhang, Chunxiao Wen, Jin Fang, Zhiyun Du, Dongling Wu, Platinum- and gold-catalyzed hydroalkoxylation and tetramerization of propiolate esters, Catalysis Communications 56 (2014) 101-105;

10. Qian Chen, Changyuan Zhang, Lili Chen, Chunxiao Wen, Zhiyun Du, Huixiong Chen, Kun Zhang, a-Monoarylation and tandem arylation–insertion of malonates with arynes, Tetrahedron Letters 56 (2015) 2094-2097;

11. Tian-Yu Sun, Kai Chen, Changyuan Zhang, Tingting You, and Penggang Yin, 1,3-O-Transposition or Trisubstituted Z-Enol Ester? A Comparative Study of Reactions of Ynones, Chem. Asian J. 2019, 14, 1941-1944;

12. Jingcheng Du, Changyuan Zhang, Hong Pu, Yufeng Li, Saimeng Jin, Luxi Tan, Cailong Zhou, Lichun Dong; HKUST-1 MOFs decorated 3D copper foam with superhydrophobicity/superoleophilicity for durable oil/water separation, Colloids and Surfaces A 573 (2019) 222-229.

学术兼职及荣誉称号

学术兼职：The Journal of Organic Chemistry杂志审稿人

2019年度科研工作先进个人；2019-2020学年度优秀教师

发明专利及获奖情况

一种苯基硫代二苯磷酸酯的制备方法，CN 110563760 B, 2022.2.11 (授权发明专利)