
杨灵光,男,汉族,1992年8月生,湖南株洲人。2019年毕业于北京林业大学生物科学与技术学院,副教授,硕士生导师,赣鄱俊才——主要学科学术带头人,江西省产业技术工程化中心副主任,宜春市技术创新中心副主任,宜春学院技术研究中心主任,宜春市科技副总,SCI期刊Frontiers in Nutrition副主编,北京化工大学博士后,中国药学会及江西省药学会成员。2019年7月参加工作,历任药学院教师,现任宜春学院发展规划处(高等教育研究所)副处长。
长期致力于结构生物学研究,聚焦于新型anti-CRISPR蛋白的结构解析、机制阐明及其作为CRISPR-Cas基因药物调控工具的研发。主持国家自然科学基金2项,江西省赣鄱俊才支持计划、江西省自然科学基金、江西省教育厅科技项目、宜春市重点研发计划项目、江西省教学改革课题各1项;发表SCI/EI收录论文30余篇,总被引761次,H指数166;在Nature Communications、Molecular Cell等国际知名期刊以通讯或第一作者发表论文16篇。多次受邀在国内外学术会议作报告,并为Nucleic Acids Research、Food & Functions等二十余本一区、二区SCI期刊审稿四十余次。签订横向项目一项,另有2项发明专利进入实质审查阶段。指导研究生获国家奖学金、江西省研究生创新课题、江西省研究生十佳“实践之星”提名奖等多项荣誉。邮箱yanglingguangxdjqz@163.com.
主要代表性成果
1 Xueli Cao, Zirui Gao, Peipei Yin*, Hao Wang*, Lingguang Yang*, Crystal structure and inhibition mechanism of AcrIIA11, Biochemical and Biophysical Research Communications, 2025, 30:772:152073.
2 Jiangping Huang, Meiting Li, Chengyun Han, Zhongwei Zhang, Xiang Liu, Zhixuan Ying, Peipei Yin*, Lingguang Yang*, Structural and mechanistic insights into the anti-tyrosinase, anti-melanogenesis, and anti-browning effect of proanthocyanidins from seed coats of Acer truncatum Bunge. International Journal of Biological Macromolecules. 2025, 284: 138246.
3 Peipei Yin, Jiangping Huang, Chuang Deng, Lingguang Yang*. Myricitrin versus EGCG in the treatment of obesity: target mining and molecular mechanism exploring based on network pharmacology. Current Pharmaceutical Design. 2023. 29(24):1939-1957.
4 Peipei Yin#, Yi Zhang#, Lingguang Yang#, et al. Non-canonical inhibition strategies and structural basis of anti-CRISPR proteins targeting type I CRISPR-Cas systems. Journal of Molecular Biology. 2023, 167996
5 Lingguang Yang#, Laixing Zhang#, Peipei Yin#, et al. Insights into the inhibition of type I-F CRISPR-Cas system by a multifunctional anti-CRISPR protein AcrIF24. Nature Communications, 2022, 13(1): 1931.
6 Lingguang Yang#, Yi Zhang#, Peipei Yin#, et al. Structural Insights into the Inactivation of the Type I-F CRISPR-Cas System by Anti-CRISPR Proteins, RNA Biology, 2021, 18(sup2):562-573.
7 Yiying Niu#, Lingguang Yang#, Teng Gao#, et al. A Type I-F Anti-CRISPR Protein Inhibits the CRISPR-Cas Surveillance Complex by ADP-Ribosylation, Molecular Cell, 2020, 80(3): 512-524.e5


