易聪，浙江大学医学院百人计划研究员浙江大学医学院“百人计划”研究员，博士生导师。中国生物物理学会膜生物物理分会理事，中国生物物理学会线粒体生物学分会理事，Biophysics Reports青年编委。课题组受到国家重点研发计划“前沿生物技术”重点专项、基金委优青项目、基金委重大研究计划集成项目、基金委重大研究计划培育项目、基金委面上项目、浙江省杰青项目及浙江省杰青延续项目等经费资助。邮箱：yiconglab@zju.edu.cn
主要研究方向
1.能量代谢与细胞自噬之间的内在关联；
2.选择性自噬发生的分子机制及生理病理意义；
3 细胞稳态在代谢性疾病、神经退行性疾病以及癌症发生发展过程中的作用机制。
主要科学发现
（1）阐明了能量代谢调控自噬发生的分子机制，揭示了能量应激条件下自噬调控的独特规律；（2）鉴定了核糖体自噬受体RPL12和固态聚集体自噬受体CCT2，阐明了其在核糖体质量控制和固态聚集体清除中的调控机制和重要作用；（3）解析了自噬相关蛋白逐级装配的分子基础，揭示了自噬体组装过程中蛋白互作的层级调控规律。这些发现从自噬起始阶段的应激感应、底物识别到机器组装三个维度，构建了自噬调控的新理论框架。近年来发表的第一作者或通讯作者论文包括Science、Cell、Nature Cell Biology、Dev Cell、EMBO J、PNAS、JCB、EMBO Reports、Autophagy等。上述论文或被Science作为亮点进行介绍、或被Nature Reviews Molecular Cell Biology、Nature Cell Biology、Molecular Cell、Science Signaling进行亮点评论、或被Faculty1000收录并推荐。
代表性成果
1Siyu Fan#, Huan Yang#, Jianting Lei, Xinyue Gong, Yiyu Lin, Yuan Zhou, Yuhang Cui, Yuanyuan Ding, Mingzhu Fan, Shan Feng, Weijing Yao, Dong Fang, Kunrong Mei, Hongguang Xia*, Cong Yi*. The SWR1 complex prevents the vacuolar delivery of ATG proteins through a non-canonical pathway. Journal of Cell Biology, in press.
2Yi Zhang#, Yingcong Chen#, Choufei Wu#, Zhengyi Cai, Weijing Yao, Huan Yang, Juan Song, Xiankuan Xie*, Liqin Zhang*, Cong Yi*. Establishment of a yeast essential protein conditional-degradation library and screening for autophagy-regulating genes. Autophagy. 2025 Mar 4:1-13. doi: 10.1080/ 15548627.2025.2469189.
3Siyu Fan, Shuling Dong, Weijing Yao, Yi Zhang, Mingzhu Fan, Shan Feng, Choufei Wu, Liqin Zhang, Cong Yi*. Mec1-mediated Atg9 phosphorylation regulates the PAS recruitment of Atg9 vesicles upon energy stress. PNAS. 2025 Feb 11;122(6):e2422582122.
4Yuting Chen#, Jiaxin Hu#, Pengwei Zhao#, Jie Fang#, Yingqi Kuang, Zhaojie Liu, Shuling Dong, Weijing Yao, Yuanyuan Ding, Xinhui Wang, Yibin Pan, Jianbin Wu, Jingwei Zhao, Jing Yang, Zhenzhong Xu, Xiaodi Liu, Yi Zhang, Choufei Wu, Liqin Zhang, Mingzhu Fan, Shan Feng, Zhi Hong, Zhangming Yan, Hongguang Xia, Kaiyue Tang, Bing Yang, Wei Liu, Qiming Sun, Kunrong Mei*, Wei Zou*,Yunpeng Huang*, Du Feng*, Cong Yi*. Rpl12 is a conserved ribophagy receptor. Nature Cell Biology. 2025 Feb 11. doi: 10.1038/ s41556 -024-01598-2.
5Yuting Chen#, Zhaojie Liu#, Yi Zhang#, Miao Ye, Yingcong Chen, Jianhua Gao, Juan Song, Huan Yang, Choufei Wu, Weijing Yao, Xue Bai, Mingzhu Fan, Shan Feng, Yigang Wang, Liqin Zhang, Liang Ge, Du Feng*, Cong Yi*. Two distinct regulatory pathways govern Cct2-Atg8 binding in the process of solid aggrephagy. EMBO reports. 2024 Nov;25(11):4749-4776.
6Weijing Yao#, Yingcong Chen#, Yi Zhang#, Shu Zhong#, Miaojuan Ye, Yuting Chen, Siyu Fan, Miao Ye, Huan Yang, Yixing Li, Choufei Wu, Mingzhu Fan, Shan Feng, Zhaoxiang He, Long Zhou, Liqin Zhang, Yigang Wang, Wei Liu, Jingjing Tong*, Du Feng*, Cong Yi*. Ca2+-triggered Atg11-Bmh1/2-Snf1 complex assembly initiates autophagy upon glucose starvation. Journal of Cell Biology, 2024 Sep 2;223(9): e202310049.
7Weijing Yao#, Yuting Chen#, Yingcong Chen#, Pengwei Zhao#, Jing Liu, Yi Zhang, Qiang Jiang, Choufei Wu, Yu Xie, Siyu Fan, Miao Ye, Yigang Wang, Yuyao Feng, Xue Bai, Mingzhu Fan, Shan Feng, Juan Wang, Yixian Cui, Hongguang Xia, Cheng Ma, Zhiping Xie, Liqin Zhang, Qiming Sun, Wei Liu, Cong Yi*. TOR-mediated Ypt1 phosphorylation regulates autophagy initiation complex assembly. EMBO J, 2023 Aug 28. e112814.
8Weijing Yao#, Yixing Li#, Yingcong Chen#, Yuting Chen#, Pengwei Zhao, Yi Zhang, Qiang Jiang, Yuyao Feng, Fan Yang, Choufei Wu, Huiming Zhong, Yiting Zhou, Qiming Sun, Liqin Zhang, Wei Liu, Cong Yi*. Mec1 regulates PAS recruitment of Atg13 via direct binding with Atg13 during glucose starvation-induced autophagy. PNAS. 2023 Jan 3;120(1): e2215126120.
9Weijing Yao#, Yixing Li#, Yingcong Chen#, Yuting Chen#, Yu Xie, Miaojuan Ye, Ying Zhang, Xiangjun Chen, Xiaoyong Wu, Yuyao Feng, Zhi Hong, Yigang Wang, Wei Liu, Cong Yi*. Atg1-mediated Atg11 phosphorylation is required for selective autophagy by regulating its association with receptor proteins. Autophagy. 15 Apr 2022.
10Xinyu Ma, Caijing Lu, Yuting Chen, Shulin Li, Ningjia Ma, Xuan Tao, Ying Li, Jing Wang, Min Zhou, Yong-Bin Yan, Pilong Li, Kartoosh Heydari, Haiteng Deng, Min Zhang*, Cong Yi*, Liang Ge*. CCT2 is an aggrephagy receptor for clearance of solid protein aggregates. Cell. 2022 April; 185, 1–21.
11Weijing Yao, Yixing Li, Liming Wu, Choufei Wu, Yi Zhang, Jing Liu, Zhiyong He, Xiaoyong Wu, Chenjun Lu, Liefeng Wang, Huiming Zhong, Zhi Hong, Shiming Xu, Wei Liu,Cong Yi*. Atg11 is required for initiation of glucose starvation-induced autophagy. Autophagy, 2020 Dec;16(12):2206-2218.
12Cong Yi#, Jingjing Tong#, Puzhong Lu, Yizheng Wang, Jinxie Zhang, Chen Sun, Kangning Yuan, Renyu Xue, Bing Zou, Nianzhong Li, Shuhua Xiao, Chong Dai, Yuwei Huang, Liling Xu, Lin Li, She Chen, Di Miao, Haiteng Deng, Hongliang Li & Li Yu*. Formation of a Snf1-Mec1-Atg1 Module on Mitochondria Governs Energy Deprivation-Induced Autophagy by Regulating Mitochondrial Respiration. Developmental Cell，2017, 41(1): 59-71.
13Cong Yi, Meisheng Ma, Leili Ran, Jingxiang Zheng, Jingjing Tong, Jing Zhu, Chengying Ma, Yufen Sun, Shaojin Zhang, Wenzhi Feng, Liyuan Zhu, Yan Le, Xingqi Gong, Xianghua Yan, Bing Hong, FenJun Jiang, Zhiping Xie, Di Miao, Haiteng Deng & Li Yu* Function and molecular mechanism of acetylation in autophagy regulation. Science, 2012, 336(6080): 474-477.
