周婕，女，汉族，1990年3月生，江西宜春人，2015年博士毕业于中山大学药理学专业，副教授，硕士生导师。江西省细胞生物学学会青年工作委员会委员，国家自然科学基金函评专家。2015年9月参加工作，为基础医学院药理学教研室教师。主持国家自然科学基金2项，江西省自然科学基金1项，江西省教育厅科学技术研究项目2项。发表学术论文30余篇，其中SCI论文20余篇，中文核心期刊以上论文10余篇，邮箱：zj9032@126.com。
研究方向为药物毒理学，主要研究药物所致脏器损伤的分子机制及其干预策略。聚焦于氧化应激、细胞程序性死亡等在肝、肾等器官毒性中的作用，通过阐明药物引发毒性的具体机制，为相关毒性损伤的预防和治疗提供潜在的靶点与理论依据。
（1）课题
1、国家自然科学基金地区科学基金项目，82460815，Nrf2/FSP1通路在七叶皂苷钠诱导铁死亡致肾毒性中的作用及机制研究，2025/01-2028/12，主持。
2、江西省自然科学基金青年基金项目，20252BAC200583，栀子苷经Nrf2/PRDX6/GPX4通路抑制铁死亡减轻六价铬肾毒性的机制研究，2025/06-2028/05，主持。
（2）获奖
指导2021级硕士研究生获评2025年江西省优秀硕士学位论文。
（3）论文
1、Xin Zheng, Wei Wu, Yurou Li, Wupei Pan, Yinan Xu, Lianwei Zhong, Yinjie Jiang, Jie Zhou*. Matrine triggers cardiotoxicity via apoptosis induced by reduction of GSH synthesis through the ATF4/CTH pathway [J]. Toxicology and Applied Pharmacology, 2025, 506: 117654.
2、Jie Zhou*, Yurou Li, Chen Xi, Wupei Pan, Qin Yu, Zhengping Wu. Apigenin alleviates fumonisin B1-induced hepatotoxicity by suppressing ferroptosis through the Nrf2/FSP1 pathway [J]. Journal of Agricultural and Food Chemistry, 2025, 73(42):26999-27011.
3、Xin Zheng, Xinyi Tang, Yinan Xu, Haiyan Zhu, Lianwei Zhong, Chen Chen, Jiajun Cui, Jie Zhou*. Sodium aescinate induces hepatotoxicity through apoptosis and ferroptosis by inhibiting the Nrf2/CTH pathway [J]. Journal of Ethnopharmacology, 2025, 345: 119608.
4、Chen Xi, Jie Zhou*, Xin Zheng, Xiaoyi Fu, Minjuan Xie. Sodium aescinate-induced hepatotoxicity via ATF4/GSH/GPX4 axis-mediated ferroptosis [J]. Scientific Reports, 2025,15(1):1141.
5、Jie Zhou*, Xin Zheng, Chen Xi, Xinyi Tang, Yinjie Jiang, Minjuan Xie, Xiaoyi Fu. Cr(VI) induced hepatocyte apoptosis through the CTH/H2S/Drp1 signaling pathway [J]. Science of the Total Environment, 2024, 950: 175332.
6、Haiyan Zhu, Yijing Yang, Yenan Duan, Xin Zheng, Zixiong Lin, Jie Zhou*. Nrf2/FSP1/CoQ10 axis-mediated ferroptosis is involved in sodium aescinate-induced nephrotoxicity [J]. Archives of Biochemistry and Biophysics, 2024, 759: 110100.
7、Xi Wang, Zixiong Lin, Xinyi Tang, Minjuan Xie, Ting Li, Jie Zhou*. Matrine induces cardiotoxicity by promoting ferroptosis through the Nrf2 antioxidant system in H9c2 cells [J]. Toxicology Letters. 2024, 397:11-22.
8、Haiyan Zhu, Yenan Duan, Yijing Yang, Enqing Chen, Hanxin Huang, Xi Wang, Jie Zhou*. Sodium aescinate induces renal toxicity by promoting Nrf2/GPX4-mediated ferroptosis [J]. Chemico-Biological Interactions. 2024, 391:110892.
9、Xi Wang, Zixiong Lin, Ting Li, Wenjing Zhu, Hanxin Huang, Jiayan Hu, Jie Zhou*. Sodium Selenite Prevents Matrine Induced Nephrotoxicity by Suppressing Ferroptosis via the GSH GPX4 Antioxidant System [J]. Biological Trace Element Research, 2024, 202(10):4674-4686.
10、Xi Wang, Wenjing Zhu, Miao Xing, Haiyan Zhu, Enqing Chen, Jie Zhou*. Matrine disrupts Nrf2/GPX4 antioxidant system and promotes hepatocyte ferroptosis [J]. Chemico-Biological Interactions. 2023, 384: 110713.
11、Miao Xing, Xiaoyu Ma, Xi Wang, Haoze Wang, Minjuan Xie, Ziwen Zhang, Jie Zhou*. Emodin disrupts the Notch1/Nrf2/GPX4 antioxidant system and promotes renal cell ferroptosis [J]. Journal of Applied Toxicology. 2023,43(11):1702-1718.
12、Tianyang Wang, Jian Zhang, Haokai Wei, Xi Wang, Minjuan Xie, Yinjie Jiang, Jie Zhou*. Matrine-induced nephrotoxicity via GSK-3β/nrf2-mediated mitochondria-dependent apoptosis [J]. Chemico-Biological Interactions. 2023, 378: 110492.
13、席晨, 魏静瑶, 周婕*. 苦参碱通过抑制CBS/H2S/ATP5A通路诱导肝毒性[J]. 中国药理学通报. 2025, 41(7): 1283-1289.
14、姜银杰, 罗霜, 张彦哲, 焦阳, 笪明珍, 周婕*. 一枝黄花提取物下调 cyclinA1/CDK2 通路抑制肝癌细胞增殖、迁移与侵袭[J]. 中国新药与临床杂志. 2023,42(4):233-239.
